Turmeric is a wildly grown SAF plant native to southeast India known for its anti-inflammatory, anti-microbial and anti-neoplastic properties. Also known as curcuma longa (part of the ginger family), it is rich in SAF nutrients called curcuminoids, most notable among them is curcumin, which occurs in the rhizomes and roots. Curcumin consists about 3% of the dried turmeric powder.
Mechanisms of actions
Animal studies have shown that tumeric’s active ingredient curcumin interferes with key molecular pathways involved in cancer formation and metastasis. It has been reported to inhibit cancer-causing enzymes in rodents. Recent studies have shown that curcumin induces growth inhibiting effects and reduces development of several forms of cancer in lab animals. Human studies reveal that due to poor absorption curcumin needs to be taken in large dosages in order to reach the circulation. However, even though it has poor absorption to the blood circulation, curcumin has shown a greater absorption capacity into the colon lining and related cancerous tissues. A recent study revealed that curcumin supplementation reduced the incidence of abnormal crypt foci in smokers. Other studies indicate that turmeric (the whole plant) induces cholesterol lowering, anti-inflammatory and anti-ulceration effects. More studies are needed to elucidate the mechanism of actions behind turmeric (the whole plant) in general and curcumin in particular.
- Chemo-protective (activates vitamin D receptor and mimics its chemo-preventing effects)
- Anti-neoplastic (suppresses several stages of tumerogenesis by lowering concentrations of pro-carcinogenic substances in the colon and rectum; inhibits nuclear factor kappa B pathway in breast cancer cells and blocks metastasis)
- Gastro-protective (protects against gastric ulcers via suppression of H2 histamin receptors)
- Anti-inflammatory (inhibits the pro-inflammatory nuclear factor kappa B pathway; suppresses cyclooxygenase expression)
- Vitamin D mimicking effects (mimics the stress response activities of vitamin D)
- Anti-fungal, anti-bacterial (toxic effects of SAF nutrients in whole tumeric on pathological microbes)
- Neuro protective (helps block plaques and formation of beta amyloid proteins in the brain that cause neuro-degenerative diseases)
More research is needed to find what is the safety threshold for turmeric and what is the potential risk for drug to drug interactions. Some people may be sensitive to turmeric, allergic reactions are possible.
SAF Stress-Response Complex
SAF Stress-Response Complex combines the most potent SAF nutrients specifically selected to mimic the effects of fasting and exercise on the body. These hard to find nutrients are specially sourced from barks, roots, rhizomes and leaves into one exclusive package. The formula includes berberine, salicin, green tea, resveratrol and turmeric to yield the right nutritional complexity at the right biological potency. Jump start your SAF experience with SAF Stress-Response Complex.
Aggarwal BB, Shishodia S, Takada Y, et al. Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice. Clin Cancer Res. 2005;11:7490-7498. Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. Bioavailability of curcumin: problems and promises. Mol Pharm. 2007;4:807-818. Carroll RE, Benya RV, Turgeon DK, et al. Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia. Cancer Prev Res (Phila). 2011 Mar;4(3):354-64. Cheng AL, Hsu CH, Lin JK, et al. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res. 2001 Jul-Aug;21(4B):2895-2900. Deshpande SS, Ingle AD, Maru GB. Inhibitory effects of curcumin-free aqueous turmeric extract on benzo[a]pyrene-induced forestomachpapillomas in mice. Cancer Lett. 1997;118:79-85. Egan ME, Pearson M, Weiner SA, et al. Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects. Science. 2004;304:600-602. Goel A, Kunnumakkara AB, Aggarwal BB.Curcumin as “Curecumin”: from kitchen to clinic. BiochemPharmacol. 2008;75:787-809. Hastak K, Lubri N, Jakhi SD, et al. Effect of turmeric oil and turmeric oleoresin on cytogenetic damage in patients suffering from oral submucous fibrosis. Cancer Lett. 1997:116:265-269. Kim DC, Kim SH, Choi BH, et al. Curcuma longa extract protects against gastric ulcers by blocking H2 histamine receptors. Biol Pharm Bull. 2005;28:2220-2224. Kunnumakkara AB, Diagaradjane P, Guha S, et al. Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-kappaB-regulated gene products. Clin Cancer Res. 2008;14:2128-2136. Lin YG, Kunnumakkara AB, Nair A, et al. Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factor-kappaB pathway. Clin Cancer Res. 2007;13:3423-3430. Mall M, Kunzelmann K. Correction of the CF defect by curcumin: hypes and disappointments. Bioessays. 2005;27:9-13. Memorial Sloan-Kettering Cancer Center.Turmeric.Accessed at www.mskcc.org/cancer-care/herb/turmeric on December 7, 2012. Rafatullah S, Tariq M, Al-Yahya MA, Mossa JS, Ageel AM.Evaluation of turmeric (Curcuma longa) for gastric and duodenal antiulcer activity in rats.J Ethnopharmacol. 1990;29:25-34. Rasyid A, Rahman AR, Jaalam K, Lelo A. Effect of different curcumin dosages on human gall bladder. Asia Pac J ClinNutr. 2002;11(4):314-318. Sharma RA, Euden SA, Platton SL, et al. Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance. Clin Cancer Res. 2004;10:6847-6854. Tunstall RG, Sharma RA, Perkins S, et al. Cyclooxygenase-2 expression and oxidative DNA adducts in murine intestinal adenomas: modification by dietary curcumin and implications for clinical trials. Eur J Cancer. 2006;42:415-421. Vareed SK, Kakarala M, Ruffin MT, et al. Pharmacokinetics of curcumin conjugate metabolites in healthy human subjects. Cancer Epidemiol Biomarkers Prev. 2008 Jun;17(6):1411-7. Yang F, Lim GP, Begum AN, et al. Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem. 2005;280:5892-5901.