SAF Nutrients: Resveratrol

SAF Nutrients Resveratrol

Resveratrol is a SAF nutrient pholyphenol produced by several plants in response to stress such as from radiation, heat shock, or microbial attack. It has been shown to increased survivability and life-span of the consuming organisms by activating the same genes as those activated by calorie restriction.

Dietary Source

Resveratrol is found in ripe berries, grapes (primarily the skin), peanuts (sprouted, boiled or roasted), red wine, Japanese knotweed, dark chocolate and white pine.

Mechanisms of action

Resveratrol activates the SIRT-1 gene in animals along with AMPK and the transcriptional coactivator PGC-1α, which altogether exert similar health and fitness effects as calorie restriction and exercise. It has shown to increase insulin sensitivity, reduce IGF-1 (insulin like growth factor 1), increase mitochondrial biogenesis, prevent mitochondrial damage, increase fat oxidation, improve motor function and reduce body fat.

In vitro, resveratrol has shown to increase SOD levels, which act to reduce superoxide O2, a major oxidative radical byproduct of mitochondrial energy production. (These effects have been observed via the pathway resveratrol → SIRT-1/NAD → FOXO30 → MnSOD.)


  • Calorie restriction and exercise like effects (activation of SIRT-1 and AMPK, inhibition of mTOR, increased mitochondrial biogenesis, increased fat oxidation)
  • Anti-aging (activation of SIRT-1, increased cellular NAD dependent deacetylase, increased cellular factor cAMP, increased AMPK and inhibition of mTOR)
  • Anti-neoplastic (inhibition of mTOR and growth, apoptotic effects on cancer cells, anti-angiogenic activity, increased resistance to oxidative damage)
  • Increased resistance to aging (decreased organ pathology, improved motor function, increased insulin sensitivity, reduced inflammation)
  • Immune support (increased expression of the transcriptional coactivator PGC-1a, increased mitochondrial biogenesis, reduction of superoxide O2, upregulation of glutathione peroxidase GPX)
  • Neuro-protection (protection against neuronal cell dysfunction and cell death in vitro)
  • Testosterone support (increased testosterone production via selective inhibition of the aromatase enzyme that converts testosterone to estrogen)
  • Increased cellular repair (increased autophagy and cellular renovation via inhibition of mTOR)
  • Skin protection (protection against ultraviolet radiation related damage)



Given the evidence that resveratrol is an estrogen inhibitor (due to its anti-aromatase activity) and a potent topoisomerase inhibitor (enzyme that’s essential for the survivability of the fetus), it should not be used by women who are pregnant or intent to be pregnant. It should not be taken by children as there isn’t sufficient evidence on how it affects the growing young.


SAF Stress-Response Complex

SAF Stress-Response Complex combines the most potent SAF nutrients specifically selected to mimic the effects of fasting and exercise on the body. These hard to find nutrients are specially sourced from barks, roots, rhizomes and leaves into one exclusive package. The formula includes berberine, salicin, green tea, resveratrol and turmeric to yield the right nutritional complexity at the right biological potency.

Jump start your SAF experience with SAF Stress-Response Complex.



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