What I’m about to tell you is not like anything you ever heard or read.As the founder and author of The Warrior Diet, I’ve helped hundreds of thousands of men and women in the US and millions around the world follow a healthy diet built specifically around cutting edge science of ancestral nutrition and how humans are supposed to function. But my search for a better life led me deeper than I could’ve ever imagined.
With my first book, I proved that there was a world beyond “3 – 5 meals a day” — that reducing the number of meals per day alone helps prevent problems like obesity, diabetes, and even premature aging.
But that wasn’t enough. There was so much more.
I was always intrigued by the science of stress and how it can benefit our lives. Even more so I was interested in ways to apply this information for improving human nutrition and health. So I went down the rabbit hole.
Over the past few years, I privately amassed a team of university researchers to learn just exactly how stress and food impact us in ways besides mere gaining or losing body fat, muscle, and energy. The results were staggering and conclusive:
Food makes your body old (and sick) because it’s missing certain nutrients activated by stress. And incredibly, the same food could keep you young and healthy if it had stress activated nutrients.
These are nutrients you probably never heard of. Their benefits go far beyond those of vitamins and antioxidants. Once circulated in your system; they act to mimic the effects of fasting and exercise. And although they’ve been in our food chain for thousands of years, we don’t get enough of them anymore; they’ve essentially been eliminated from our modern food chain. The research kept proving that over and over again, and it turned out we were sitting on a huge discovery.
Imagine nutrients that give your body the health benefits of fasting and exercise without the hunger and hardship involved.
If you want to learn more about these critical nutrients. I’d like to show you dietary choices that may not only pack more life in your years, but more years in your life.
That’s why I created SAF.
Now, this will NOT fix all your wrinkles overnight or turn you into a twenty-year-old in seven days. What it will do, however, is show you a new path to a revitalized body — more energy, less fat, better life quality – and superior capacity to resist stress.
SAF stands for “Stress Activated Food”. It means food raised under stress. The reason why food is called “Stress Activated” is because stress activates molecules in the food that make it notably superior.
These molecules are called SAF nutrients.
SAF is indeed a superior food. It comes from die-hard species including plants, animals and fish which struggle to survive as they search for food and fight the elements. Examples of SAF include wild plants that are underfed (non-fertilized), pasture raised grass-fed animals and their products (milk, cheese and whey), free range chickens and their eggs and wild catch fish whose habitat is stressed by extreme climate conditions.
What’s unique about SAFs is the fact that they are stressed. Consider SAF a stress-hardened food similar to a battle hardened soldier. It does not only outperforms conventional food, it yields unmatched benefits that no conventional food can provide.
While conventional food provides vitamins, minerals and calories to keep you going, SAF provides unique nutrients that can potentially transform your body and extend your life. The SAF impact goes far and beyond the limits of conventional thinking.
Berberine is a SAF nutrient alkaloid reported to mimic the effects of calorie restriction, exercise on the body and increased fatty acid oxidation…Read More
Salicin is a SAF nutrient which possess potent anti- inflammatory, anti- microbial, antioxidant and anti-neoplastic properties…Read More
Green tea (camellia sinensis) is a rich source of SAF nutrients polyphenols – catechins, quercitin and myricetin – which have been shown to enhance…» Read More
Resveratrol is a SAF nutrient pholyphenol produced by several plants in response to stress such as from radiation, heat shock, or microbial…Read More
Turmeric is a wildly grown SAF plant native to southeast India known for its anti-inflammatory, anti-microbial and anti-neoplastic properties…» Read More
SAF nutrients signal your body to resist stress and rejuvenate. Certain SAF nutrients impact your body like dieting and exercising as proven by research trials. They turn on metabolic pathways that lower blood sugar, increase fat burning and reduce inflammation. This unique phenomenon has no equivalent in nature.
SAF nutrients block metabolic processes that would normally make you fat and old.
They literally put the brakes on the mechanism that drives aging. And they do that by turning on the same genes as those triggered by exercise and fasting. Only that while exercise is limited to the length of your workout and fasting is restricted to the duration of your fast, SAF nutrients continue impacting your body for as long as they circulate in your system. And they benefit you even when you sleep. It’s incredible to feel how your body gets supercharged with these molecules.
Following is a summary of some key research papers supporting the evidence that berberine is a potent activator of the stress-response pathway AMPK and thereby mimics the anti-obesity and blood sugar lowering effects of calorie restriction and exercise on the body. Other SAF nutrients that exert similar effects as calorie restriction and exercise are salicin and resveratrol.
In 2004, Kong et al. reported that oral administration of berberine to hypercholesterolemic patients for 3 months produced clinically significant reductions in total serum cholesterol, triglycerides and LDL cholesterol (29%, 35% and 25%, respectively), highly beneficial effects that may be at least partially achieved by appropriate diet and exercise. Kong et al. also reported even greater reductions in serum cholesterol and LDL-cholesterol in hyperlipidemic hamsters.
Bursq et al. (2006) found similar inhibition by berberine of cholesterol and triglyceride synthesis in vitro in human hepatocellular carcinoma cells (a widely used in vitro model for human liver cells), and showed the action to be due to berberine’s activation of the enzyme adenosine monophosphate-activated protein kinase (AMPK). The authors noted that AMPK had been proposed to play a key role in the regulation of lipid metabolism, as has since been confirmed in numerous studies.
Some of this recent research on the role of AMPK is summarized in the review article “Sensing of energy and nutrients by AMP-activated protein kinase” by D.G. Hardie in the American Journal of Clinical Nutrition (2011). The article explains how AMPK functions, and also notes the activation of AMPK by berberine, salicin and resveratrol:
In mammals, AMPK is activated by an increasing cellular AMP:ATP ratio (which signifies a decrease in energy) caused by metabolic stresses that interfere with ATP production (eg, fasting, hypoxia) or accelerate ATP consumption (eg, muscle contraction). Because glucose deprivation can increase the AMP:ATP ration, AMPK can also act as a glucose sensor…
Once activated, AMPK switches on catabolic pathways that generate ATP (eg, via increased uptake and oxidation of glucose and fatty acids along with increased mitochondrial biogenesis while switching off AP-consuming, anabolic pathways (eg, the synthesis of lipids, glucose, glycogen, and proteins).
These features make AMPK an ideal drug target in the treatment of metabolic disorders such as insulin resistance and type 2 diabetes. Some xenobiotics or nutraceuticals, including the SAF nutrients berberine, resveratrol, quercetin, and salicin are AMPK activators. Most of these nutrients activate AMPK because they disrupt mitochondrial ATP production.
Thus, Hardie indicates that AMPK is activated by such actions as muscle contraction (i.e., exercise) and glucose deprivation (i.e., calorie restriction), and by such substances as berberine, salicin and resveratrol (all of which are SAF nutrients).
Ichinoseki-Sekine et al. (2009), in a paper published in the American Journal of Physiology, Endocrinology and Metabolism, also describe the various function of AMPK relevant to the calorie restriction and exercise mimicking effects of SAF nutrients on the body as follows:
AMP-activated protein kinase (AMPK) is a sensor and regulator of cellular energy balance that modulates the consumption and regeneration of ATP. AMPK is activated by a decrease in the intracellular ATP-to-AMP ratio, which occurs under various types of stress, such as nutrient deprivation, hypoxia, and heat shock at the cellular level and starvation, ischemia, and exercise at the tissue and whole body levels. In addition to the regulation of cellular energy balance in peripheral organs, AMPK is involved in the regulation of energy homeostasis at the whole body level by regulating feeding behavior through its actions on the hypothalamus.
Since the connections between obesity and insufficient exercise/excess caloric intake on the one hand, and between obesity and type 2 diabetes, hypertension and dyslipidemia 1 (collectively termed “metabolic syndrome”) on the other hand, are well established, studies on the effects of berberine on both obesity and the diabetic state are relevant to the claim above.
For example, Lee et al. (2006) studied the effects of berberine on db/db mice (an animal model of diabetes, obesity and dyslipidemia) and on high-fat-fed rats. In the obese, diabetic mice, which received berberine via i.p. injection for 26 days, body weight fell significantly (about 13%) while normal control mice gained weight at the expected rate, although food intake remained virtually the same in both groups. Post-mortem examination indicated the following –
A clear loss of adipose tissue in the berberine-treated obese mice, the result of a decrease in the size rather than the number of fat cells. A significant reduction in fasting blood glucose levels and a significant improvement in glucose tolerance were also reported in the treated mice, while these parameters remained unchanged in the normal mice.
Berberine was also administered orally by gavage for 2 weeks to groups of rats fed either standard chow or a high-fat diet. Both groups showed a significant reduction in body weight gain compared to non-berberine-fed controls, but with no corresponding change in food intake. In addition, berberine significantly lowered plasma triglycerides and reduced insulin resistance in high-fat-fed rats but produced no such changes in rats fed normal chow. Accompanying in vitro studies showed that –
Berberine down-regulated genes involved in lipogenesis (fat formation, specifically the formation of fatty acids from acetyl-CoA) and up regulated genes involved in energy expenditure in both adipose tissue and muscle; it also increased AMPK activity.
Zhou et al. (2007) performed a somewhat longer in vivo study of berberine in rats. Berberine or water control was administered orally by gavage for 6 weeks to rats on a high-fat diet.
Berberine-treated rats gained significantly less weight (as did their livers and epididymal fat) than high-fat-fed control rats. Plasma triglycerides, total cholesterol, LDL-cholesterol and free fatty acids were significantly reduced in the berberine-treated rats compared to controls. Berberine treatment also resulted in reductions in fasting plasma glucose and insulin to levels comparable to those in rats fed a normal chow.
After glucose loading, plasma glucose and insulin levels of berberine-treated rats were consistenly lower than those of high-fat-fed control rats. Accompanying in vitro work in pancreatic MIN6 cells showed that berberine acutely increased AMPK activity.
Kim et al. (2009) reported that –
Berberine treatment (daily i.p. injection for 3 weeks) in db/db mice significantly reduced body weight (but not food intake), liver weight, hepatic and plasma triglycerides and cholesterol levels compared to vehicle-treated control mice, and promoted AMPK activity and fatty acid oxidation in both the liver and muscle.
Some authorsnote that orally administered berberine has poor bioavailability due to limited absorption from the intestine, and high dose oral administration intended to compensate for this may cause undesirable gastrointestinal effects, which tend to limit its clinical usefulness.
Zhang et al. (2012), in a study of the effects of berberine on the AMPK gluconeogenesis pathway in the diabetic rat model, investigated the effects of co-administered sodium caprate, a medium-chain fatty acid, as an absorption enhancer. Rats were either normal controls fed regular chow, or diabetes-induced animals fed a high-fat diet. Diabetic animals were divided into six groups: those receiving no treatment (diabetic controls), those receiving berberine alone at two different dose levels (50 or 100 mg/kg/day), those receiving berberine at the two different dose levels, plus sodium caprate (50 mg/kg/day), and those receiving sodium caprate alone. After 4 weeks treatment, a glucose tolerance test was conducted, and fasting plasma levels of triglycerides, total cholesterol and glucose were measured. Fasting blood glucose, triglycerides and total cholesterol were significantly higher in the diabetic controls than in the normal controls. As in earlier animals studies,
Berberine treatment reduced body weight gain (but not food intake) compared to diabetic controls, and significantly lowered triglyceride levels towards those of normal controls. The high dose of berberine (but not the low dose) also significantly reduced fasting blood glucose and cholesterol.
Sodium caprate augmented the effect of berberine on all these parameters, although statistical significance compared to berberine alone was only achieved in the case of fasting blood glucose, and then only at the high dose of berberine. Total cholesterol was significantly reduced by berberine compared to diabetic control at the high dose levels. Sodium caprate also augmented the beneficial effect of berberine (high dose only) on glucose tolerance, and berberine’s activation of AMPK by phosphorylation. Sodium caprate alone had no effect on any parameters.
Brusq JM, Ancellin N, Grondin P, Guillard R, Martin S, Saintillan Y, Issandou M. Inhibition of lipid synthesis through activation of AMP kinase: an additional mechanism for the hypolipidemic effects of berberine. J Lipid Res. 2006 Jun;47(6):1281-8.
Hardie DG. Sensing of energy and nutrients by AMP-activated protein kinase. Am J ClinNutr.2011 Apr;93(4):891S-6.
Ichinoseki-SekineN, Naito H, Tsuchihara K, Kobayashi I, Ogura Y, Kakigi R, Kurosaka M,Fujioka R, Esumi H. Provision of a voluntary exercise environment enhances running activity and prevents obesity in Snark-deficient mice. Am J Physiol Endocrinol Metab. 2009 May;296(5):EI013-21.
Kim WS, Lee YS, Cha SH, Jeong HW, Choe SS, Lee MR, Oh GT, Park HS, Lee KU, Lane MD, Kim JB. Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK activity.Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E812-9.
Kong W, Wei J, Abidi P, Lin M, Inaba S, Li C, Wang Y, Wang Z, Si S, Pan H, Wang S, Wu J,Wang Y, Li Z, Liu J, Jiang JD. Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nat Med. 2004 Dec;10(12): 1344-51.
Lee YS, Kim WS, Kim KH, Yo on MJ, Cho HJ, Shen Y, Ye JM, Lee CH, Oh WK, Kim CT, Hohnen-Behrens C, Gosby A, Kraegen EW, James DE, Kim JB. Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes. 2006 Aug;55(8):2256-64.
Zhang M, Lv X, Li J, Meng Z, Wang Q, Chang W, Li W, Chen L, Liu Y. Sodium caprate augments the hypoglycemic effect of berberine via AMPK in inhibiting hepatic gluconeogenesis. Mol Cell Endocrinol. 2012 Nov 5;363(1 -2):122-30.
Zhou L, Wang X, Shao L, Yang Y, Shang W, Yuan G, Jiang B, Li F, Tang J, Jing H, Chen M. Berberine acutely inhibits insulin secretion from beta-cells through 3′,5′-cyclic adenosine 5′-onophosphate signaling pathway. Endocrinology. 2008 Sep;149(9):4510-8.
Chan AY, Dolinsky VW, Soltys CL, Viollet B, Baksh S, Light PE, et al. Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and Akt. J Biol Chem 2008;283:24194-201.
Dasgupta B, Milbrandt J. Resveratrol stimulates AMP kinase activity in neurons. Proc Natl Acad Sci.
Juan ME, Alfaras I, Planas JM. Colorectal cancer chemoprevention by trans-resveratrol. Pharmacol Res 2012;65:584-5891.
Hawley, S. A.; Fullerton, M. D.; Ross, F. A.; Schertzer, J. D.; Chevtzoff, C.; Walker, K. J.; Peggie, M. W.; Zibrova, D. et al. (2012). “The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase”. Science 336 (6083).
You may notice some side effects similar to those of fasting and exercise. These may include lower blood sugar and detox-like effects. Nonetheless, you’ll most likely get adept to SAF nutrition the same way you adapt to exercise. Some people might be sensitive to certain SAF nutrients, particularly salicin, which may affect those who are allergic to salysilic acid.
You can now enjoy the outstanding health benefits of berberine. This bark derived nutrient has been reported to possess qualities that no other nutrient has.
Berberine turns on metabolic switches that burn fat, lower cholesterol, lower blood sugar, increase resistance to illness and stress, and even delay aging.
And it does that by activating the same pathways that are triggered during fasting and exercise. Most notable among them is the AMPK pathway. When activated by berberine, AMPK inhibits processes that make you gain fat and cholesterol, while increasing your capacity to burn fat and lose weight.
Furthermore, science has been proving that berberine has the unique capacity to block mTOR, the mechanism that when overstimulated,turns your body inflamed and sick while accelerating the aging process.
We’ve put years of research in crafting SAF strategy and making these special nutrients finally available.
For more information on berberine
SAF Stress-Response Complex combines the most potent SAF nutrients specifically selected to mimic the effects of fasting and exercise on the body. These hard to find nutrients are specially sourced from barks, roots, rhizomes and leaves into one exclusive package. The formula includes berberine, salicin, green tea, resveratrol and turmeric to yield the right nutritional complexity at the right biological potency.
Jump start your SAF experience with SAF Stress-Response Complex.
To learn more about SAF Stress-Response Complex.
Introducing our brand-new SAF Green Tea. It provides your body with special nutrients called catechins to help you block stress and feel recuperated within. Green tea has been proven through massive body of research to help burn body fat, boost energy, improve cognitive functions, prevent brain diseases, and help the body defend against the wear and tear of time while boosting its natural process of flushing out toxins and rejuvenating.
The SAF line was created to help you sustain peak shape and if needed, fight back and reclaim your health by giving your body the specific nutrients it craves to thrive on… nutrients that you can’t get from your typical diet.
To learn more about SAF Green Tea.